Is the cerebellum a potential target for stimulation in Parkinson's disease? Results of 1-Hz rTMS on upper limb motor tasks
Language English Country United States Media print
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Single-Blind Method MeSH
- Middle Aged MeSH
- Humans MeSH
- Motor Skills physiology MeSH
- Cerebellum physiology MeSH
- Parkinson Disease physiopathology therapy MeSH
- Arm physiology MeSH
- Psychomotor Performance physiology MeSH
- Reaction Time physiology MeSH
- Aged MeSH
- Transcranial Magnetic Stimulation methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
The aim of this study was to find whether 1-Hz cerebellar repetitive transcranial magnetic stimulation (rTMS) could affect upper limb movement in early-stage Parkinson's disease (PD). Twenty patients with PD underwent one session with real and one with sham rTMS. rTMS (1 Hz, 600 pulses) was targeted at the right lateral cerebellum. Before and after rTMS, patients performed two motor tests with their fingers and hands (ball test, nine-hole peg test). The duration of these tests was measured. There were statistically significant differences (p < 0.05) in the results of the tests after real stimulation and sham stimulation. We excluded the impact of learning. After real rTMS, we observed a significantly faster response in the ball test and a slower response in the nine-hole peg test, both on the right upper limb. This study indicates the influence of 1-Hz cerebellar rTMS in modifying the voluntary movements of the upper limb in PD. This influence is differentiated: the improvement of gross motor skills and the worsening of fine motor skills.
See more in PubMed
Cerebellum. 2009 Sep;8(3):302-11 PubMed
Exp Brain Res. 1996 Apr;109(1):158-63 PubMed
Am J Occup Ther. 2003 Sep-Oct;57(5):570-3 PubMed
Clin Neurophysiol. 2008 Mar;119(3):504-532 PubMed
Exp Brain Res. 2007 Jan;176(3):440-7 PubMed
Exp Brain Res. 2007 May;179(2):291-9 PubMed
Clin Neurophysiol. 2008 May;119(5):1139-46 PubMed
Cerebellum. 2010 Mar;9(1):124-35 PubMed
J Neurol. 2009 Feb;256(2):256-63 PubMed
J Physiol. 1997 Feb 1;498 ( Pt 3):817-23 PubMed
J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1110-6 PubMed
Ann Neurol. 1995 Jun;37(6):703-13 PubMed
Exp Brain Res. 2008 Feb;184(4):521-8 PubMed
Arch Neurol. 2002 Mar;59(3):413-7 PubMed
Hum Brain Mapp. 2009 May;30(5):1502-10 PubMed
J Neurol. 2003 Jan;250(1):42-50 PubMed
Tohoku J Exp Med. 1999 Nov;189(3):203-11 PubMed
Neurology. 2009 Jul 14;73(2):113-9 PubMed
Eur J Neurosci. 2009 Nov;30(10):1971-9 PubMed
Clin Neurophysiol. 2005 Feb;116(2):244-53 PubMed
Cerebellum. 2008;7(4):572-6 PubMed
Electroencephalogr Clin Neurophysiol. 1992 Dec;85(6):355-64 PubMed
J Neurol Sci. 2003 Sep 15;213(1-2):35-45 PubMed
Exp Brain Res. 2009 Feb;192(4):651-6 PubMed
PLoS Biol. 2007 Nov;5(11):e316 PubMed
J Neurol Sci. 2004 Feb 15;217(2):205-10 PubMed
Exp Brain Res. 2007 Jun;180(2):355-65 PubMed
Eur J Neurol. 2003 Jul;10(4):385-9 PubMed
Parkinsonism Relat Disord. 2007 Dec;13(8):489-94 PubMed
Neurosci Lett. 2005 Mar 16;376(3):188-93 PubMed
Clin Neurophysiol. 2002 Sep;113(9):1435-40 PubMed
Rev Esp Med Nucl. 2009 May-Jun;28(3):114-20 PubMed
Neuropsychologia. 1971 Mar;9(1):97-113 PubMed
J Physiol. 1993 Nov;471:501-19 PubMed
J Physiol. 2004 Jun 1;557(Pt 2):689-700 PubMed
Neurosci Lett. 2001 Jun 22;306(1-2):29-32 PubMed
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Jun;154(2):133-9 PubMed
Neurosci Lett. 2004 Nov 23;371(2-3):185-9 PubMed
