Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu klinické zkoušky kontrolované, časopisecké články, práce podpořená grantem
- MeSH
- aplikace orální MeSH
- biomarkery farmakologické metabolismus MeSH
- cytochrom P-450 CYP2D6 genetika metabolismus MeSH
- dospělí MeSH
- lidé MeSH
- mióza chemicky indukované MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mydriáza chemicky indukované MeSH
- opioidní analgetika aplikace a dávkování farmakokinetika farmakologie MeSH
- polymorfismus genetický MeSH
- pupila účinky léků MeSH
- tramadol aplikace a dávkování farmakokinetika farmakologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky kontrolované MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biomarkery farmakologické MeSH
- cytochrom P-450 CYP2D6 MeSH
- opioidní analgetika MeSH
- tramadol MeSH
WHAT IS KNOWN AND OBJECTIVE: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. METHODS: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0·7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. RESULTS AND DISCUSSION: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69·6% and mydriasis in 30·4% of the subjects. The pupillary response differed in relation to the CYP2D6 genotype. A maximal difference in initial pupil diameter of 0·81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0·05) except for the reflex amplitude and constriction velocity. WHAT IS NEW AND CONCLUSION: The pharmacodynamic effects of tramadol were easily detected using both static and dynamic pupil parameters. The pharmacodynamic profiles were markedly influenced by the CYP2D6 phenotype.
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