Antibacterial nanofiber materials activated by light
Language English Country United States Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21972201
DOI
10.1002/jbm.a.33218
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Escherichia coli drug effects MeSH
- Photosensitizing Agents chemistry MeSH
- Caprolactam analogs & derivatives chemistry MeSH
- Nanofibers chemistry MeSH
- Oxidants chemistry MeSH
- Hydrogen Peroxide chemistry MeSH
- Polyesters chemistry MeSH
- Polymers chemistry MeSH
- Polystyrenes chemistry MeSH
- Polyurethanes chemistry MeSH
- Porphyrins chemistry MeSH
- Singlet Oxygen chemistry MeSH
- Light * MeSH
- Materials Testing MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 5,10,15,20-tetraphenylporphyrin MeSH Browser
- Anti-Bacterial Agents MeSH
- Photosensitizing Agents MeSH
- Caprolactam MeSH
- nylon 6 MeSH Browser
- Oxidants MeSH
- Hydrogen Peroxide MeSH
- polycaprolactone MeSH Browser
- Polyesters MeSH
- Polymers MeSH
- Polystyrenes MeSH
- Polyurethanes MeSH
- Porphyrins MeSH
- Singlet Oxygen MeSH
Electrospun polymeric nanofiber materials doped with 5,10,15,20-tetraphenylporphyrin (TPP) photosensitizer were prepared from four different polymers and were characterized with microscopic methods, steady-state, and time-resolved fluorescence and absorption spectroscopy. The polymers used included polyurethane Larithane™ (PUR), polystyrene (PS), polycaprolactone (PCL), and polyamide 6 (PA6). The antibacterial activity of all nanofiber materials against E. coli was activated by visible light and it was dependent on oxygen permeability/diffusion coefficients and the diameter of the polymeric nanofibers. This activity is based on oxidation ability of singlet oxygen O₂(¹Δ(g)) that is generated upon irradiation. All tested nanofiber materials exhibited prolonged antibacterial properties, even in the dark after long-duration irradiation. The post-irradiation effect was explained by the photogeneration of H₂O₂, which provided the material with long-lasting antibacterial properties.
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