Statins and their influence on brain cholesterol
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21981838
DOI
10.1016/j.jacl.2011.06.007
PII: S1933-2874(11)00614-3
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease metabolism MeSH
- Cholesterol metabolism MeSH
- Databases, Factual MeSH
- Blood-Brain Barrier metabolism MeSH
- Humans MeSH
- Brain drug effects metabolism MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Cholesterol MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors MeSH
BACKGROUND: Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is not clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones. SOURCES OF MATERIAL: The MEDLINE database. FINDINGS: According to the data reported thus far, statins may influence brain cholesterol metabolism directly (because they are able to penetrate BBB no matter whether they are hydrophilic or lipophilic) and also indirectly (by lowering plasma cholesterol). Although the definite mechanism is not known yet, it becomes obvious that statins do not only influence peripheral but also central cholesterol pool. CONCLUSION: Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration.
References provided by Crossref.org
Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
Cholesterol modulates open probability and desensitization of NMDA receptors
