Statins and their influence on brain cholesterol
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
21981838
DOI
10.1016/j.jacl.2011.06.007
PII: S1933-2874(11)00614-3
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc metabolismus MeSH
- cholesterol metabolismus MeSH
- databáze faktografické MeSH
- hematoencefalická bariéra metabolismus MeSH
- lidé MeSH
- mozek účinky léků metabolismus MeSH
- statiny farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- cholesterol MeSH
- statiny MeSH
BACKGROUND: Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is not clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones. SOURCES OF MATERIAL: The MEDLINE database. FINDINGS: According to the data reported thus far, statins may influence brain cholesterol metabolism directly (because they are able to penetrate BBB no matter whether they are hydrophilic or lipophilic) and also indirectly (by lowering plasma cholesterol). Although the definite mechanism is not known yet, it becomes obvious that statins do not only influence peripheral but also central cholesterol pool. CONCLUSION: Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration.
Citace poskytuje Crossref.org
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