Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22862172
DOI
10.4149/neo_2012_090
Knihovny.cz E-resources
- MeSH
- ErbB Receptors physiology MeSH
- Homeostasis * MeSH
- Humans MeSH
- Cell Transformation, Neoplastic * MeSH
- Hedgehog Proteins physiology MeSH
- Receptors, Notch physiology MeSH
- Receptors, Eph Family physiology MeSH
- Wnt Signaling Pathway physiology MeSH
- Signal Transduction physiology MeSH
- Intestinal Neoplasms etiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- ErbB Receptors MeSH
- Hedgehog Proteins MeSH
- Receptors, Notch MeSH
- Receptors, Eph Family MeSH
Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine.
References provided by Crossref.org
Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
