Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22865582
DOI
10.1002/ijc.27759
Knihovny.cz E-zdroje
- MeSH
- buňky - růstové procesy imunologie MeSH
- buňky Th17 imunologie metabolismus MeSH
- CD8-pozitivní T-lymfocyty imunologie metabolismus patologie MeSH
- chemokin CCL22 imunologie metabolismus MeSH
- dendritické buňky imunologie metabolismus MeSH
- dospělí MeSH
- interferon gama imunologie metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- makrofágy imunologie metabolismus MeSH
- monocyty imunologie metabolismus MeSH
- nádorové buněčné linie MeSH
- nádorové mikroprostředí imunologie MeSH
- nádory vaječníků imunologie metabolismus patologie MeSH
- progrese nemoci MeSH
- receptory CCR4 imunologie metabolismus MeSH
- regulační T-lymfocyty imunologie metabolismus MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tumor infiltrující lymfocyty imunologie metabolismus patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CCL22 protein, human MeSH Prohlížeč
- CCR4 protein, human MeSH Prohlížeč
- chemokin CCL22 MeSH
- interferon gama MeSH
- receptory CCR4 MeSH
The type of immune cells that are present within the tumor microenvironment can play a crucial role in the survival of patients. However, little is known about the dynamics of the tumor-infiltrating immune cells during disease progression. We studied the immune cells that infiltrated the tumor tissues of ovarian cancer patients at different stages of disease. The early stages of development of ovarian carcinomas were characterized by a strong Th17 immune response, whereas in stage II patients, recruitment of high numbers of Th1 cells was observed. In disseminated tumors (Stages III-IV), we detected a dominant population of Helios(+) activated regulatory T cells (Tregs) along with high numbers of monocytes/macrophages and myeloid dendritic cells (mDCs). Tumor-infiltrating Tregs had markedly lower expression of CCR4 than circulating Tregs, and the numbers of tumor-infiltrating Tregs significantly correlated with the levels of CCL22 in ovarian tumor cell culture supernatants, suggesting their recruitment via a CCR4/CCL22 interaction. CCL22 was mainly produced by tumor cells, monocytes/macrophages and mDCs in the primary ovarian tumors, and its expression markedly increased in response to IFNγ. Taken together, the specific recruitment of Tregs, probably triggered by inflammatory stimuli, leads to a significant immune suppression in the advanced stages of ovarian cancer.
Citace poskytuje Crossref.org
Immunological configuration of ovarian carcinoma: features and impact on disease outcome
Immunological Network in Head and Neck Squamous Cell Carcinoma-A Prognostic Tool Beyond HPV Status
