Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22948089
DOI
10.1016/j.jneuroim.2012.08.001
PII: S0165-5728(12)00245-7
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease cerebrospinal fluid immunology MeSH
- Autoantigens immunology MeSH
- Autoantibodies biosynthesis cerebrospinal fluid immunology MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Humans MeSH
- Neurofilament Proteins immunology MeSH
- tau Proteins immunology MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantigens MeSH
- Autoantibodies MeSH
- neurofilament protein H MeSH Browser
- Neurofilament Proteins MeSH
- tau Proteins MeSH
The role of humoral immunity related to neuron- and disease-specific cytoskeletal proteins patients with Alzheimer disease (AD) is unknown. We measured antibodies against tau protein, light and heavy (NFH) neurofilaments using ELISA in 80 paired serum and cerebrospinal fluid (CSF) samples from patients with AD, with other dementias (OD), with neuro-inflammatory diseases (IC) and 25 controls (NC). We estimated intrathecal synthesis according to the formula (CSF/serum anti-neurocytoskeletal IgG)/(CSF/serum total IgG). AD patients had significantly higher intrathecal anti-tau and anti-NFH antibodies than the other groups. These innovative findings may hint at specific alterations in humoral anti-neurocytoskeletal immunity and selectivity in AD, which could have diagnostic and immunotherapeutic implications.
References provided by Crossref.org
Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases
