Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22948089
DOI
10.1016/j.jneuroim.2012.08.001
PII: S0165-5728(12)00245-7
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc mozkomíšní mok imunologie MeSH
- autoantigeny imunologie MeSH
- autoprotilátky biosyntéza mozkomíšní mok imunologie MeSH
- ELISA MeSH
- lidé MeSH
- neurofilamentové proteiny imunologie MeSH
- proteiny tau imunologie MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- autoantigeny MeSH
- autoprotilátky MeSH
- neurofilament protein H MeSH Prohlížeč
- neurofilamentové proteiny MeSH
- proteiny tau MeSH
The role of humoral immunity related to neuron- and disease-specific cytoskeletal proteins patients with Alzheimer disease (AD) is unknown. We measured antibodies against tau protein, light and heavy (NFH) neurofilaments using ELISA in 80 paired serum and cerebrospinal fluid (CSF) samples from patients with AD, with other dementias (OD), with neuro-inflammatory diseases (IC) and 25 controls (NC). We estimated intrathecal synthesis according to the formula (CSF/serum anti-neurocytoskeletal IgG)/(CSF/serum total IgG). AD patients had significantly higher intrathecal anti-tau and anti-NFH antibodies than the other groups. These innovative findings may hint at specific alterations in humoral anti-neurocytoskeletal immunity and selectivity in AD, which could have diagnostic and immunotherapeutic implications.
Citace poskytuje Crossref.org
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