ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23077079
DOI
10.1177/1470320312460291
PII: 1470320312460291
Knihovny.cz E-resources
- Keywords
- ACE2, polymorphism, pulse pressure, severity,
- MeSH
- Peptidyl-Dipeptidase A genetics MeSH
- Angiotensin-Converting Enzyme 2 MeSH
- Demography MeSH
- Adult MeSH
- Genetic Predisposition to Disease MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Cardiovascular Diseases diagnostic imaging enzymology genetics physiopathology MeSH
- Coronary Angiography * MeSH
- Blood Pressure * MeSH
- Middle Aged MeSH
- Humans MeSH
- Multivariate Analysis MeSH
- Pulse MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ACE2 protein, human MeSH Browser
- Peptidyl-Dipeptidase A MeSH
- Angiotensin-Converting Enzyme 2 MeSH
BACKGROUND AND AIM: The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). METHODS: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5'exonuclease (Taqman®) chemistry on the ABI Prism® 7000 system (Applied Biosystems, Foster City, CA, USA). RESULTS: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81× higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). A significant difference in allelic frequency of ACE2rs4646174 was found between women with and without significant stenoses of the circumflex branch of the left coronary artery. CONCLUSION: More research into the role of ACE2 genetic variability in PP regulations is necessary for more detailed physiological and pathophysiological comprehension of PP regulation.
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