Gitelmanův syndrom v těhotenství - těžká hypokalémie s příznivou perinatální prognózou
[Gitelman syndrome in pregnancy--a severe hypokalemia with favorable perinatal prognosis]
Jazyk čeština Země Česko Médium print
Typ dokumentu kazuistiky, anglický abstrakt, časopisecké články
PubMed
23116347
PII: 38927
- MeSH
- dospělí MeSH
- Gitelmanův syndrom * diagnóza terapie MeSH
- komplikace těhotenství * diagnóza terapie MeSH
- lidé MeSH
- novorozenec MeSH
- prognóza MeSH
- těhotenství MeSH
- výsledek těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
Gitelman syndrom is a rare congenital tubulopathy characterized by hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria. We report a case of a 32-year-old patient admitted for asymptomatic hypokalemia and hypomagnesemia in the 30th week of gestation. A diagnosis of Gitelman syndrom was made and intravenous administration of potassium chloride in high doses combined with spironolactone was started. Despite intensive potassium supplementation (8 g/day), the serum potassium levels remained at the lower limit of normality throughout the pregnancy. The patient delivered a healthy female 2670 g/48 cm after labor induction in the 39th week of gestation. A summary of 22 so far published cases of Gitelman syndrome in pregnancy is presented. The analysis of published case studies suggests a need for ion supplementation, reduction of urinary potassium wasting, monitoring of fetal well-being and amniotic fluid levels. Pregnancy has a very favorable perinatal prognosis despite critical serum levels of potassium and magnesium throughout the pregnancy.