Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články
PubMed
23353847
PII: NEL330912A10
Knihovny.cz E-zdroje
- MeSH
- antiflogistika nesteroidní toxicita MeSH
- Aspirin toxicita MeSH
- chemické látky znečišťující vodu toxicita MeSH
- dánio pruhované embryologie MeSH
- embryo nesavčí účinky léků MeSH
- kvalita vody MeSH
- LD50 MeSH
- metabolická inaktivace fyziologie MeSH
- oxidační stres účinky léků fyziologie MeSH
- testy akutní toxicity MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiflogistika nesteroidní MeSH
- Aspirin MeSH
- chemické látky znečišťující vodu MeSH
OBJECTIVES: The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme. METHODS: Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology. RESULTS: The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid. CONCLUSIONS: The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.
