Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23469978
DOI
10.2217/fon.12.200
Knihovny.cz E-zdroje
- MeSH
- adjuvantní chemoterapie MeSH
- cysteinové endopeptidasy genetika metabolismus MeSH
- dospělí MeSH
- duktální karcinom prsu enzymologie mortalita MeSH
- frekvence genu MeSH
- izoenzymy genetika metabolismus MeSH
- Kaplanův-Meierův odhad MeSH
- kaspasa 2 genetika metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA genetika metabolismus MeSH
- nádory prsu enzymologie mortalita MeSH
- neoadjuvantní terapie MeSH
- sekvenční analýza DNA MeSH
- senioři MeSH
- upregulace MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CASP2 protein, human MeSH Prohlížeč
- cysteinové endopeptidasy MeSH
- izoenzymy MeSH
- kaspasa 2 MeSH
- messenger RNA MeSH
AIM: A role of caspase-2 in chemotherapy-induced apoptosis has been suggested. Our study aimed to evaluate the prognostic and predictive importance of caspase-2 isoforms in breast cancer patients. MATERIALS & METHODS: Caspase-2L and -2S transcript levels were determined in paired tumor and non-malignant control tissues from 64 patients after neoadjuvant chemotherapy and 100 pretreatment patients (general set) by real-time PCR with absolute quantification. RESULTS: Low but statistically significant upregulation of caspase-2L in tumor versus control tissues was observed in both sets. Significant associations of the levels of caspase-2L, -2S or S/L ratio with clinical prognostic factors were observed. However, none of these associations were confirmed in both sets. Levels of caspase-2 isoforms or the S/L ratio did not significantly associate with progression-free survival in the general set or with chemotherapy response in the neoadjuvant set. CONCLUSION: Our results suggest that the role of caspase-2 isoforms in the progression of breast cancer may considerably differ between pre- and post-chemotherapy patients.
Citace poskytuje Crossref.org
