Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23469978
DOI
10.2217/fon.12.200
Knihovny.cz E-resources
- MeSH
- Chemotherapy, Adjuvant MeSH
- Cysteine Endopeptidases genetics metabolism MeSH
- Adult MeSH
- Carcinoma, Ductal, Breast enzymology mortality MeSH
- Gene Frequency MeSH
- Isoenzymes genetics metabolism MeSH
- Kaplan-Meier Estimate MeSH
- Caspase 2 genetics metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger genetics metabolism MeSH
- Breast Neoplasms enzymology mortality MeSH
- Neoadjuvant Therapy MeSH
- Sequence Analysis, DNA MeSH
- Aged MeSH
- Up-Regulation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- CASP2 protein, human MeSH Browser
- Cysteine Endopeptidases MeSH
- Isoenzymes MeSH
- Caspase 2 MeSH
- RNA, Messenger MeSH
AIM: A role of caspase-2 in chemotherapy-induced apoptosis has been suggested. Our study aimed to evaluate the prognostic and predictive importance of caspase-2 isoforms in breast cancer patients. MATERIALS & METHODS: Caspase-2L and -2S transcript levels were determined in paired tumor and non-malignant control tissues from 64 patients after neoadjuvant chemotherapy and 100 pretreatment patients (general set) by real-time PCR with absolute quantification. RESULTS: Low but statistically significant upregulation of caspase-2L in tumor versus control tissues was observed in both sets. Significant associations of the levels of caspase-2L, -2S or S/L ratio with clinical prognostic factors were observed. However, none of these associations were confirmed in both sets. Levels of caspase-2 isoforms or the S/L ratio did not significantly associate with progression-free survival in the general set or with chemotherapy response in the neoadjuvant set. CONCLUSION: Our results suggest that the role of caspase-2 isoforms in the progression of breast cancer may considerably differ between pre- and post-chemotherapy patients.
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