Metabolic profiling of phenolic acids and oxidative stress markers after consumption of Lonicera caerulea L. fruit
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23581742
DOI
10.1021/jf304150b
Knihovny.cz E-resources
- MeSH
- Anthocyanins administration & dosage MeSH
- Antioxidants metabolism MeSH
- Biomarkers urine MeSH
- Chromatography, Liquid MeSH
- Cinnamates urine MeSH
- Adult MeSH
- Erythrocytes metabolism MeSH
- Glutathione Peroxidase blood MeSH
- Hippurates urine MeSH
- Mass Spectrometry MeSH
- Hydroxybenzoates urine MeSH
- Catalase blood MeSH
- Benzoic Acid urine MeSH
- Vanillic Acid urine MeSH
- Coumaric Acids urine MeSH
- Thiobarbituric Acid Reactive Substances metabolism MeSH
- Humans MeSH
- Lipoproteins, LDL blood MeSH
- Lonicera chemistry MeSH
- Metabolome * MeSH
- Fruit chemistry MeSH
- Oxidative Stress drug effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anthocyanins MeSH
- Antioxidants MeSH
- Biomarkers MeSH
- Cinnamates MeSH
- Glutathione Peroxidase MeSH
- Hippurates MeSH
- hippuric acid MeSH Browser
- Hydroxybenzoates MeSH
- isoferulic acid MeSH Browser
- Catalase MeSH
- Benzoic Acid MeSH
- Vanillic Acid MeSH
- Coumaric Acids MeSH
- Thiobarbituric Acid Reactive Substances MeSH
- Lipoproteins, LDL MeSH
- oxidized low density lipoprotein MeSH Browser
- phenolic acid MeSH Browser
- protocatechuic acid MeSH Browser
This study investigated the effect of one-week consumption of 165 g/day fresh blue honeysuckle berries (208 mg/day anthocyanins) in 10 healthy volunteers. At the end of intervention, levels of benzoic (median 1782 vs 4156), protocatechuic (709 vs 2417), vanillic (2779 vs 4753), 3-hydroxycinnamic (143 vs 351), p-coumaric (182 vs 271), isoferulic (805 vs 1570), ferulic (1086 vs 2395), and hippuric (194833 vs 398711 μg/mg creatinine) acids by LC/MS were significantly increased in the urine. Clinical chemistry safety markers were not altered. Oxidative stress markers, erythrocyte glutathione peroxidase (0.73 vs 0.88 U/g Hb) and catalase (2.5 vs 2.8 μkat/g Hb) activities, and erythrocyte/plasma thiobarbituric acid reactive substance (522 vs 612/33 vs 38 μmol/g Hb/protein) levels were significantly increased, without change in plasma antioxidant status. Nonsignificant changes of advanced oxidation protein products and oxidized LDL were observed. The results provide a solid base for further study of metabolite excretion and antioxidant parameters after ingestion of anthocyanins.
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