Caspase-7 participates in differentiation of cells forming dental hard tissues
Language English Country Japan Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
G0901599
Medical Research Council - United Kingdom
MR/J006742/1
Medical Research Council - United Kingdom
PubMed
23713787
DOI
10.1111/dgd.12066
Knihovny.cz E-resources
- MeSH
- Ameloblasts cytology enzymology metabolism MeSH
- Cell Differentiation * MeSH
- Time Factors MeSH
- Immunohistochemistry MeSH
- Caspase 7 genetics metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Odontoblasts cytology enzymology metabolism MeSH
- Odontogenesis MeSH
- Cell Proliferation MeSH
- X-Ray Microtomography MeSH
- Incisor embryology growth & development metabolism MeSH
- Dental Enamel embryology growth & development metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Caspase 7 MeSH
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
References provided by Crossref.org
Caspase-9 Is a Positive Regulator of Osteoblastic Cell Migration Identified by diaPASEF Proteomics
Exploring caspase functions in mouse models
Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis
Making the head: Caspases in life and death
Osteogenic Potential of Caspases Related to Endochondral Ossification
Non-apoptotic functions of caspase-7 during osteogenesis
