Antibacterial, cytotoxicity and physical properties of laser--silver doped hydroxyapatite layers
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23827567
DOI
10.1016/j.msec.2012.12.018
PII: S0928-4931(12)00575-9
Knihovny.cz E-resources
- Keywords
- Antibacterial, Cytotoxicity, Hydroxyapatite, PLD, Silver, Thin films,
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Cell Death drug effects MeSH
- NIH 3T3 Cells MeSH
- X-Ray Diffraction MeSH
- Escherichia coli drug effects MeSH
- Fibroblasts cytology drug effects MeSH
- Durapatite pharmacology MeSH
- Silicon pharmacology MeSH
- Crystallization MeSH
- Lasers * MeSH
- Microbial Sensitivity Tests MeSH
- Microscopy, Electron, Scanning MeSH
- Elastic Modulus drug effects MeSH
- Mice MeSH
- Staphylococcus aureus drug effects MeSH
- Titanium pharmacology MeSH
- Hardness drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Durapatite MeSH
- Silicon MeSH
- Titanium MeSH
Hydroxyapatite layers with silver doping from 0.06 at.% to 14 at.% were prepared by laser deposition. The films' physical properties such as morphology, composition, crystallinity, Young's modulus and microhardness were measured. Films were amorphous or polycrystalline in dependence on deposition temperature (from RT to 600 °C). Antibacterial properties were tested using Escherichia coli and Bacillus subtilis cells. The antibacterial efficacy changed with silver doping from 4% to 100%. Cytotoxicity was studied by a direct contact test. Depending on doping and crystallinity the films were either non-toxic or mildly toxic.
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