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Mycobacterium avium subsp. avium and Mycobacterium neoaurum detection in an immunocompromised patient

. 2014 Apr ; 142 (4) : 882-5. [epub] 20130710

Language English Country England, Great Britain Media print-electronic

Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't

Links

PubMed 23842543
PubMed Central PMC9151095
DOI 10.1017/s0950268813001660
PII: S0950268813001660
Knihovny.cz E-resources

Non-tuberculous mycobacteria are increasingly described as infectious agents in immunocompromised patients. A 17-year-old male patient suffering from secondary non-Hodgkin's lymphoma and treated with chemotherapeutic agents was admitted to hospital due to pleuropneumonia. Mycobacterium neoaurum was cultured repeatedly from his sputum and, Mycobacterium avium subsp. avium (M. a. avium) was detected by IS901 qPCR from detached fragments of his intestinal mucosa. We attempted to determine the possible sources of infection by analysing environmental samples from the closed oncology unit and conventional unit in the hospital, and from the patient's home residence and places which he frequented. The environment of the patient harboured mycobacteria (41 isolates in total); however, M. neoaurum was not recovered. M. a. avium was detected by qPCR in the environmental samples from a small flock of hens kept by his neighbour. Although it was not confirmed by DNA fingerprinting methods, the M. a. avium infection could have been acquired through the eating of incompletely cooked eggs.

See more in PubMed

Shitaye JE, et al. Mycobacterium avium subsp. avium distribution studied in a naturally infected hen flock and in the environment by culture, serotyping and IS901 RFLP methods. Veterinary Microbiology 2008; 127: 155–164. PubMed

Moravkova M, et al. The presence of Mycobacterium avium subsp. avium in common pheasants (Phasianus colchicus) living in captivity and in other birds, vertebrates, non-vertebrates and the environment. Veterinarni Medicina 2011; 56: 333–343.

Marras TK, Daley CL. Epidemiology of human pulmonary infection with non-tuberculous mycobacteria. Clinics in Chest Medicine 2002; 23: 553–567. PubMed

Sun HY, et al. Endoscopic appearance of GI mycobacteriosis caused by the Mycobacterium avium complex in a patient with AIDS: case report and review. Gastrointestinal Endoscopy 2005; 61: 775–779. PubMed

Falkinham JO. Epidemiology of infection by nontuberculous mycobacteria. Clinical Microbiology Reviews 1996; 9: 177–215. PubMed PMC

Brown-Elliott BA, et al. Mycobacterium neoaurum and Mycobacterium bacteremicum sp. nov. as causes of mycobacteremia. Journal of Clinical Microbiology 2010; 48: 4377–4385. PubMed PMC

Morimoto Y, et al. Pulmonary infection with Mycobacterium neoaurum identified by 16S ribosomal DNA sequence. Journal of Infection 2007; 54: e227–e231. PubMed

Baird SF, et al. Cluster of non-tuberculous mycobacteraemia associated with water supply in a haemato-oncology unit. Journal of Hospital Infection 2011; 79: 339–343. PubMed

Slana I, et al. Distribution of Mycobacterium avium subsp. avium and M. a. hominissuis in artificially infected pigs studied by culture and 1S901 and IS1245 quantitative real time PCR. Veterinary Microbiology 2010; 144: 437–443. PubMed

Harmsen D, et al. RIDOM: comprehensive and public sequence database for identification of Mycobacterium species. BMC Infectious Diseases 2003; 3: 26. PubMed PMC

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