Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24091083
DOI
10.1016/j.jinf.2013.09.028
PII: S0163-4453(13)00297-1
Knihovny.cz E-zdroje
- Klíčová slova
- Blood–brain barrier, Matrix metalloproteinase-9, Tick-borne encephalitis, Tissue inhibitor of metalloproteinase-1,
- MeSH
- biologické markery krev MeSH
- dítě MeSH
- dospělí MeSH
- ELISA MeSH
- klíšťová encefalitida krev enzymologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- matrixová metaloproteinasa 9 krev MeSH
- mladiství MeSH
- mladý dospělý MeSH
- neparametrická statistika MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- tkáňový inhibitor metaloproteinasy 1 krev MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- matrixová metaloproteinasa 9 MeSH
- tkáňový inhibitor metaloproteinasy 1 MeSH
OBJECTIVES: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain barrier (BBB). To investigate the function of the BBB during tick-borne encephalitis (TBE), the levels of MMP-9 and its common tissue inhibitor, TIMP-1, were measured in serum from patients with acute phase of TBE. METHODS: Serum MMP-9 and TIMP-1 levels were measured in 147 patients with TBE and 153 controls by ELISA. RESULTS: Serum MMP-9 levels and MMP-9/TIMP-1 ratios of TBE patients were significantly higher than controls (p < 0.0001 and p < 0.005, respectively). There were no significant differences in serum TIMP-1 levels between TBE patients and controls. Serum MMP-9 and TIMP-1 levels and MMP-9/TIMP-1 ratios were not associated with age of the patients. However, TBE-positive males with TBE had higher levels of MMP-9 than TBE-positive females (p < 0.05). CONCLUSIONS: Our results suggest that the increased serum level of MMP-9 and MMP-9/TIMP-1 ratio is associated with the pathogenesis of TBE. Serum MMP-9 can serve as an indicator of breakdown of the BBB and inflammatory brain damage during TBE.
Citace poskytuje Crossref.org
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