Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24091083
DOI
10.1016/j.jinf.2013.09.028
PII: S0163-4453(13)00297-1
Knihovny.cz E-resources
- Keywords
- Blood–brain barrier, Matrix metalloproteinase-9, Tick-borne encephalitis, Tissue inhibitor of metalloproteinase-1,
- MeSH
- Biomarkers blood MeSH
- Child MeSH
- Adult MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Encephalitis, Tick-Borne blood enzymology MeSH
- Middle Aged MeSH
- Humans MeSH
- Matrix Metalloproteinase 9 blood MeSH
- Adolescent MeSH
- Young Adult MeSH
- Statistics, Nonparametric MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Tissue Inhibitor of Metalloproteinase-1 blood MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Matrix Metalloproteinase 9 MeSH
- Tissue Inhibitor of Metalloproteinase-1 MeSH
OBJECTIVES: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain barrier (BBB). To investigate the function of the BBB during tick-borne encephalitis (TBE), the levels of MMP-9 and its common tissue inhibitor, TIMP-1, were measured in serum from patients with acute phase of TBE. METHODS: Serum MMP-9 and TIMP-1 levels were measured in 147 patients with TBE and 153 controls by ELISA. RESULTS: Serum MMP-9 levels and MMP-9/TIMP-1 ratios of TBE patients were significantly higher than controls (p < 0.0001 and p < 0.005, respectively). There were no significant differences in serum TIMP-1 levels between TBE patients and controls. Serum MMP-9 and TIMP-1 levels and MMP-9/TIMP-1 ratios were not associated with age of the patients. However, TBE-positive males with TBE had higher levels of MMP-9 than TBE-positive females (p < 0.05). CONCLUSIONS: Our results suggest that the increased serum level of MMP-9 and MMP-9/TIMP-1 ratio is associated with the pathogenesis of TBE. Serum MMP-9 can serve as an indicator of breakdown of the BBB and inflammatory brain damage during TBE.
References provided by Crossref.org
History of Arbovirus Research in the Czech Republic
Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons
