Life cycle of Cryptosporidium muris in two rodents with different responses to parasitization
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24128742
DOI
10.1017/s0031182013001637
PII: S0031182013001637
Knihovny.cz E-resources
- MeSH
- Cryptosporidium growth & development physiology MeSH
- Species Specificity MeSH
- Feces parasitology MeSH
- Cryptosporidiosis parasitology pathology MeSH
- Disease Models, Animal MeSH
- Murinae MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Oocysts MeSH
- Life Cycle Stages * MeSH
- Trophozoites MeSH
- Gastric Mucosa pathology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
This study focuses on mapping the life cycle of Cryptosporidium muris in two laboratory rodents; BALB/c mice and the southern multimammate rat Mastomys coucha, differing in their prepatent and patent periods. Both rodents were simultaneously experimentally inoculated with viable oocysts of C. muris (strain TS03). Animals were dissected and screened for the presence of the parasite using a combined morphological approach and nested PCR (SSU rRNA) at different times after inoculation. The occurrence of first developmental stages of C. muris in stomach was detected at 2.5 days post-infection (dpi). The presence of Type II merogony, appearing 36 h later than Type I merogony, was confirmed in both rodents. Oocysts exhibiting different size and thickness of their wall were observed from 5 dpi onwards in stomachs of both host models. The early phase of parasitization in BALB/c mice progressed rapidly, with a prepatent period of 7.5-10 days; whereas in M. coucha, the developmental stages of C. muris were first observed 12 h later in comparison with BALB/c mice and prepatent period was longer (18-21 days). Similarly, the patent periods of BALB/c mice and M. coucha differed considerably, i.e. 10-15 days vs chronic infection throughout the life of the host, respectively.
References provided by Crossref.org
Hide-and-Seek: A Game Played between Parasitic Protists and Their Hosts
Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016
