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Article

PubMed

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Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe--an ECCO-EpiCom study

Journal of Crohn's & colitis. 2014 Jul ; 8 (7) : 607-16. [epub] 20131207

J Crohns Colitis
ISSN 1876-4479 | 1873-9946
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid24315795

PubMed 24315795
DOI 10.1016/j.crohns.2013.11.021
PII: S1873-9946(13)00410-8
Knihovny.cz E-resources

Keywords
Environmental factors, Inception cohort, Inflammatory bowel disease, Population-based,
MeSH
Appendectomy statistics & numerical data MeSH
Crohn Disease epidemiology pathology therapy MeSH
Adult MeSH
Hospitalization statistics & numerical data MeSH
Dietary Sucrose MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Young Adult MeSH
Whooping Cough epidemiology MeSH
Dietary Fiber statistics & numerical data MeSH
Mumps epidemiology MeSH
Prospective Studies MeSH
Fast Foods statistics & numerical data MeSH
Surveys and Questionnaires MeSH
Risk Factors MeSH
Aged, 80 and over MeSH
Aged MeSH
Measles epidemiology MeSH
Severity of Illness Index MeSH
Colitis, Ulcerative epidemiology pathology therapy MeSH
Vaccination statistics & numerical data MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Young Adult MeSH
Male MeSH
Aged, 80 and over MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Geographicals
Europe epidemiology MeSH
Names of Substances
Dietary Sucrose MeSH
Dietary Fiber MeSH

BACKGROUND AND AIMS: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. METHODS: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. RESULTS: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p<0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p<0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p<0.01). CONCLUSIONS: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

1st Department of Medicine Semmelweis University Budapest Hungary

1st Division of Internal Medicine and Hepato Gastroenterology Unit University Hospital Ioannina Greece

Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania

Department of Gastroenterology Adelaide and Meath Hospital TCD Dublin Ireland

Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere Finland

Department of Gastroenterology and Hepatology Soroka Medical Center and Ben Gurion University of the Negev Beer Sheva Israel

Department of Gastroenterology Hospital de São João Porto Portugal; Institute of Pharmacology and Therapeutics Oporto Medical School Porto Portugal; Institute for Molecular and Cell Biology University of Porto Porto Portugal

Department of Gastroenterology Moscow Regional Research Clinical Institute Moscow Russian Federation

Department of Gastroenterology State University of Medicine and Pharmacy of the Republic of Moldova Chisinau Republic of Moldova

Department of Internal Medicine Section of Gastroenterology and Hepatology The National University Hospital Reykjavik Iceland

Department of Medical Gastroenterology Gentofte Hospital Copenhagen Denmark

Department of Medical Gastroenterology Odense University Hospital Odense Denmark