Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24333664
DOI
10.1016/j.ejpb.2013.12.002
PII: S0939-6411(13)00384-6
Knihovny.cz E-resources
- Keywords
- Backing layer, Carmellose, In vitro testing, In vivo evaluation, Method of impregnation, Mucoadhesive buccal films, Multivariate data analysis, Non-woven textile, Residence time, Solvent casting method,
- MeSH
- Adhesives administration & dosage chemistry metabolism MeSH
- Adhesiveness drug effects MeSH
- Administration, Buccal MeSH
- Chemistry, Pharmaceutical MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Multivariate Analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Carboxymethylcellulose Sodium administration & dosage chemistry metabolism MeSH
- Mouth Mucosa drug effects metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adhesives MeSH
- Carboxymethylcellulose Sodium MeSH
Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. The addition of polyethylene oxide prolonged the in vivo film residence time (from 53.24±5.38-74.18±5.13 min to 71.05±3.15-98.12±1.75 min), and even more when combined with an ethylcellulose backing layer (98.12±1.75 min) and also improved the film's appearance. Tested non-woven textile shortened the in vivo film residence time (from 74.18±5.13-98.12±1.75 min to 53.24±5.38-81.00±8.47 min) and generally worsened the film's appearance. Mucoadhesive buccal films with a hydrophobic backing layer were associated with increased frequency of adverse effects.
Clinic of Oral and Maxillofacial Surgery University Hospital Brno Brno Czech Republic
Department of Maxillo Facial Surgery University Hospital Ostrava Ostrava Czech Republic
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