Host response to Borrelia afzelii in BALB/c mice tested by immunoblotting
Language English Country Poland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24364462
PII: 1081399
Knihovny.cz E-resources
- MeSH
- Antigens, Bacterial immunology MeSH
- Borrelia burgdorferi Group classification MeSH
- Immunoblotting * MeSH
- Lyme Disease immunology microbiology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Antibodies, Bacterial blood MeSH
- Antibody Specificity MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Antibodies, Bacterial MeSH
The aim was to find if there is variability in the production of specific antibodies by BALB/c mice to certain antigens of three individual Borrelia afzelii (dead cell suspension) strains originally isolated from different sources. Analysis of the borrelian proteins immunogenicity was performed and determined to particular strains by immunoblotting. Some differences in production of specific IgM and IgG antibodies in each individual group of tested mice were found. The antigenic influence of OspA and OspC proteins appeared to be the most important for the induction of protective immune reaction. OspC was produced both in early and late infection of all individuals and OspA induced production of IgG antibodies in all groups of immunized mice.
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