Selective aortic arch perfusion enables to avoid deep hypothermic circulatory arrest for extirpation of renal cell carcinoma with tumour thrombus extension into the right atrium
Language English Country England, Great Britain Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24384500
PubMed Central
PMC3957292
DOI
10.1093/icvts/ivt545
PII: ivt545
Knihovny.cz E-resources
- Keywords
- Cerebral perfusion, Circulatory arrest, Deep hypothermia, Intracardiac tumour thrombus, Renal cell carcinoma,
- MeSH
- Aorta, Thoracic physiopathology surgery MeSH
- Time Factors MeSH
- Operative Time MeSH
- Neoplasm Invasiveness MeSH
- Carcinoma, Renal Cell pathology surgery MeSH
- Cardiac Surgical Procedures * adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Kidney Neoplasms pathology surgery MeSH
- Nephrectomy * adverse effects MeSH
- Perfusion adverse effects methods MeSH
- Regional Blood Flow MeSH
- Aged MeSH
- Heart Atria pathology surgery MeSH
- Treatment Outcome MeSH
- Circulatory Arrest, Deep Hypothermia Induced * adverse effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVES: Renal cell carcinoma with a tumour thrombus extending into the right heart chambers necessitates extensive combined urological and cardiac surgery. Maximum safety and exactness in extirpation of the caval and intracardiac thrombus is achieved under deep hypothermic circulatory arrest, at a price of its non-physiological burden and time constraints. We propose a simple surgical manoeuvre enabling selective arch perfusion allowing for a milder hypothermia and liberal interval of circulatory arrest. METHODS: On a routine cardiopulmonary bypass via median sternotomy, the dissection is extended along the aortic arch to identify the origins of the supra-aortic vessels. After standard aortic cross-clamping and cardioplegic cardiac arrest at moderate hypothermia, a second cross-clamp is applied at the aortic arch beyond the left carotid artery. A selective closed aortic arch perfusion is started while the extirpation of the tumour thrombus from the right atriotomy and abdominal cavotomy is being performed under conditions of circulatory arrest. RESULTS: Using selective aortic arch perfusion, successful and uncomplicated extirpation of voluminous caval and intracardiac tumour thrombi was accomplished in 3 presented patients. Unexpectedly difficult thrombus adhering to hepatic veins in 1 patient required 42 min of circulatory arrest. Postoperative courses were uneventful in all 3 patients. CONCLUSIONS: Second aortic cross-clamp to start selective closed aortic arch perfusion provides excellent surgical control of the operative field over a liberal time interval during circulatory arrest under milder hypothermia.
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Nesbitt JC, Soltero ER, Dinney CP, Walsh GL, Schrump DS, Swanson DA, et al. Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus. Ann Thorac Surg. 1997;63:1592–600. PubMed
Dominik J, Moravek P, Zacek P, Vojacek J, Brtko M, Podhola M, et al. Long-term survival after radical surgery for renal cell carcinoma with tumour thrombus extension into the right atrium. BJU Int. 2013;111:E59–64. PubMed
Franke UF, Wahlers T, Wittwer T, Schubert J. Renal carcinoma with caval vein infiltration and triple coronary disease: one-stage surgical management. Eur J Cardiothorac Surg. 2001;20:877–9. PubMed
Kpodonu J, Cusimano RJ, Robinette MA. Renal cell carcinoma with right atrial extension. Asian Cardiovasc Thorac Ann. 2007;15:364. PubMed
Nogales Asensio JM, Gonzales Frenandez MR, Bravo MA, Herrera AM. Kidney tumour mimicking cardiac mass. Int J Cardiol. 2006;106:401–3. PubMed
Posacioglu H, Ayik MF, Zeytunlu M, Amanvermez D, Engin C, Apaydin AZ. Management of renal cell carcinoma with intracardiac extension. J Card Surg. 2008;23:754–8. PubMed
Glazer AA, Novick AC. Long-term followup after surgical treatment for renal cell carcinoma extending into the right atrium. J Urol. 1996;155:448–50. PubMed
Granberg CF, Boorjian SA, Schaff HV, Orszulak TA, Leibovich BC, Lohse CM, et al. Surgical management, complications, and outcome of radical nephrectomy with inferior vena cava tumor thrombectomy facilitated by vascular bypass. Urology. 2008;72:148–52. PubMed
Horvath G, Toth C, Szentgyorgyi L, Szerafin T, Flasko T, Peterffy A. [Surgical treatment of malignant renal tumors invading the inferior vena cava and right atrium] Magy Seb. 2003;56:239–41. PubMed
Chiappini B, Savini C, Marinelli G, Suarez SM, Di Eusanio M, Fiorani V, et al. Cavoatrial tumor thrombus: single-stage surgical approach with profound hypothermia and circulatory arrest, including a review of the literature. J Thorac Cardiovasc Surg. 2002;124:684–8. PubMed
Kalkat MS, Abedin A, Rooney S, Doherty A, Faroqui M, Wallace M, et al. Renal tumours with cavo-atrial extension: surgical management and outcome. Interact CardioVasc Thorac Surg. 2008;7:981–5. PubMed
Laas J, Schmid C, Allhoff E, Borst HG. Tumor-related obstruction of the inferior vena cava extending into the right heart--a plea for surgery in deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 1991;5:653–6. PubMed
Shahian DM, Libertino JA, Zinman LN, Leonardi HK, Eyre RC. Resection of cavoatrial renal cell carcinoma employing total circulatory arrest. Arch Surg. 1990;125:727–31. discussion 731–722. PubMed
Schimmer C, Hillig F, Riedmiller H, Elert O. Surgical treatment of renal cell carcinoma with intravascular extension. Interact CardioVasc Thorac Surg. 2004;3:395–7. PubMed
Welz A, Schmeller N, Schmitz C, Reichart B, Hofstetter A. Resection of hypernephromas with vena caval or right atrial tumor extension using extracorporeal circulation and deep hypothermic circulatory arrest: a multidisciplinary approach. Eur J Cardiothorac Surg. 1997;12:127–32. PubMed
Wotkowicz C, Libertino JA, Sorcini A, Mourtzinos A. Management of renal cell carcinoma with vena cava and atrial thrombus: minimal access vs median sternotomy with circulatory arrest. BJU Int. 2006;98:289–97. PubMed
Modine T, Haulon S, Zini L, Fayad G, Destrieux-Garnier L, Azzaoui R, et al. Surgical treatment of renal cell carcinoma with right atrial thrombus: early experience and description of a simplified technique. Int J Surg. 2007;5:305–10. PubMed
Rannikko A, Sipponen J, Nordling S, Ruutu M. Cavoatrial extension of renal cell cancer: results of operative treatment in Helsinki University Hospital between 1990 and 2000. Scand J Surg. 2004;93:213–6. PubMed
Shudo Y, Matsumiya G, Sakaguchi T, Fujita T, Yamauchi T, Sawa Y. Resection of advanced stage malignant retroperitoneal neoplasms with tumor thrombus extending into the right atrium: report of four cases. Surg Today. 2011;41:262–5. PubMed
Swierzewski DJ, Swierzewski MJ, Libertino JA. Radical nephrectomy in patients with renal cell carcinoma with venous, vena caval, and atrial extension. Am J Surg. 1994;168:205–9. PubMed
Vogt PR, Ensner R, Pretre R, Schmidli J, Reuthebuch O, Zund G, et al. Less invasive surgical treatment of renal cell carcinomas extending into the right heart and pulmonary arteries: surgery for renal cell carcinoma. J Card Surg. 1999;14:330–3. PubMed
Chowdhury UK, Mishra AK, Seth A, Dogra PN, Honnakere JH, Subramaniam GK, et al. Novel techniques for tumor thrombectomy for renal cell carcinoma with intraatrial tumor thrombus. Ann Thorac Surg. 2007;83:1731–6. PubMed
Onorati F, Santini F, Telesca M, Veraldi GF, Faggian G, Mazzucco A. Avoiding sternotomy and cardiopulmonary bypass in type IV renal carcinoma: is it really worth it? Ann Thorac Surg. 2011;91:640–1. author reply 641–642. PubMed
Ciancio G, Gonzalez J, Shirodkar SP, Angulo JC, Soloway MS. Liver transplantation techniques for the surgical management of renal cell carcinoma with tumor thrombus in the inferior vena cava: step-by-step description. Eur Urol. 2011;59:401–6. PubMed
Gorin MA, Gonzalez J, Garcia-Roig M, Ciancio G. Transplantation techniques for the resection of renal cell carcinoma with tumor thrombus: A technical description and review. Urol Oncol. 2013;31:1780–7. PubMed