Predictive and prognostic significance of tumor-infiltrating lymphocytes in patients with breast cancer treated with neoadjuvant systemic therapy
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24596349
PII: 34/3/1115
Knihovny.cz E-resources
- Keywords
- Breast cancer, review, targeted therapy, tumor-infiltrating lymphocytes,
- MeSH
- Humans MeSH
- Breast Neoplasms diagnosis immunology therapy MeSH
- Neoadjuvant Therapy * MeSH
- Prognosis MeSH
- Lymphocytes, Tumor-Infiltrating immunology pathology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Despite the progress of tailored therapeutic strategies in patients with breast cancer, there is an unmet medical need for additional biomarkers that would guide therapy, including the administration of targeted agents. It has been demonstrated that the presence of tumor-infiltrating lymphocytes (TILs) is associated with prognosis in patients with early breast cancer. Moreover, TIL counts were shown to predict outcome of neoadjuvant chemotherapy. The neoadjuvant setting is increasingly used to assess the efficacy of new systemic therapies, and TILs are promising as a biomarker reflecting the immune response to tumor. Future studies should investigate on the integration of TILs as predictive biomarkers in patients treated with targeted- agents.
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