Disturbed default mode network connectivity patterns in Alzheimer's disease associated with visual processing
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24799341
DOI
10.3233/jad-131208
PII: Y7477621420J4145
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, default mode network, functional MRI, posterior cingulate, visual processing,
- MeSH
- Alzheimer Disease pathology MeSH
- Oxygen blood MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain Mapping * MeSH
- Brain blood supply physiopathology MeSH
- Nerve Net blood supply pathology MeSH
- Neuropsychological Tests MeSH
- Image Processing, Computer-Assisted MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Visual Pathways blood supply physiopathology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxygen MeSH
Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD) and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus. Additional connectivity changes (decreases) in AD were present between the posterior cingulate and superior temporal gyrus when switching from baseline to task condition. These changes are probably related to both disturbed visual processing and the DMN connectivity in AD and reflect deficits and compensatory mechanisms within the large scale brain networks in this patient population. Studying the DMN connectivity using psychophysiological interactions analysis may provide a sensitive tool for exploring early changes in AD and their dynamics during the disease progression.
References provided by Crossref.org
Disruption of resting functional connectivity in Alzheimer's patients and at-risk subjects
