Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
T32 HL007111
NHLBI NIH HHS - United States
PubMed
24836846
PubMed Central
PMC4454459
DOI
10.1016/j.eplepsyres.2014.04.002
PII: S0920-1211(14)00105-3
Knihovny.cz E-zdroje
- Klíčová slova
- Catheter ablation, Cerebral cortex, Epilepsy, Radiofrequency, Venous system,
- MeSH
- epilepsie patologie patofyziologie chirurgie MeSH
- katetrizační ablace škodlivé účinky přístrojové vybavení metody MeSH
- magnetické pole MeSH
- mapování mozku MeSH
- miniinvazivní chirurgické výkony škodlivé účinky přístrojové vybavení metody MeSH
- modely nemocí na zvířatech MeSH
- mozková kůra krevní zásobení patologie patofyziologie chirurgie MeSH
- neurochirurgické výkony škodlivé účinky přístrojové vybavení metody MeSH
- Papio MeSH
- psi MeSH
- studie proveditelnosti MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. METHODS: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. RESULTS: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. CONCLUSION: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach.
Access Point Technologies Rogers MN United States
Division of Neurology Department of Internal Medicine Mayo Clinic Rochester MN United States
Zobrazit více v PubMed
Bower MR, Stead M, et al. Intravenous recording of intracranial, broadband EEG. J Neurosci Methods. 2013;214(1):21–26. PubMed PMC
Choi H, Sell RL, et al. Epilepsy surgery for pharmacoresistant temporal lobe epilepsy: a decision analysis. JAMA. 2008;300(21):2497–2505. PubMed
Engel J., Jr Etiology as a risk factor for medically refractory epilepsy: a case for early surgical intervention. Neurology. 1998;51(5):1243–1244. PubMed
Engel J, Jr, Wiebe S, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology. 2003;60(4):538–547. PubMed
Haissaguerre M, Shah DC, et al. Electrophysiological breakthroughs from the left atrium to the pulmonary veins. Circulation. 2000;102(20):2463–2465. PubMed
Haissaguerre M, Shah DC, et al. Mapping-guided ablation of pulmonary veins to cure atrial fibrillation. Am J Cardiol. 2000;86(9A):9K–19K. PubMed
Henz BD, Friedman PA, et al. Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: possible implications for treating CNS disorders. Epilepsy Res. 2008;80(2-3):213–218. PubMed
Kara T, Leinveber P, et al. Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter technology. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2012 PubMed
Najm I, Jehi L, et al. Temporal patterns and mechanisms of epilepsy surgery failure. Epilepsia. 2013;54(5):772–782. PubMed
Stephen LJ, Kelly K, et al. Pharmacological outcomes in older people with newly diagnosed epilepsy. Epilepsy Behav. 2006;8(2):434–437. PubMed
Van Gompel JJ, Bower MR, et al. Swine model for translational research of invasive intracranial monitoring. Epilepsia. 2011;52(6):e49–53. PubMed PMC
Wyllie E, Chee M, et al. Temporal lobe epilepsy in early childhood. Epilepsia. 1993;34(5):859–868. PubMed
