Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: results from the multi-center set study
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
24907902
DOI
10.1016/j.jneuroim.2014.04.012
PII: S0165-5728(14)00123-4
Knihovny.cz E-zdroje
- Klíčová slova
- Cytomegalovirus, Deep gray matter atrophy, Environmental factors, Epstein–Barr virus,
- MeSH
- antigeny virové imunologie MeSH
- antivirové látky terapeutické užití MeSH
- atrofie farmakoterapie etiologie virologie MeSH
- časové faktory MeSH
- demyelinizační nemoci komplikace farmakoterapie MeSH
- dospělí MeSH
- Herpesviridae imunologie MeSH
- interferon beta terapeutické užití MeSH
- leukoencefalopatie etiologie MeSH
- lidé MeSH
- longitudinální studie MeSH
- magnetická rezonanční tomografie MeSH
- mladý dospělý MeSH
- neurodegenerativní nemoci etiologie MeSH
- pozorování MeSH
- protilátky virové krev MeSH
- thalamus patologie MeSH
- virové plášťové proteiny imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Názvy látek
- antigeny virové MeSH
- antivirové látky MeSH
- Epstein-Barr viral capsid antigen MeSH Prohlížeč
- interferon beta MeSH
- protilátky virové MeSH
- virové plášťové proteiny MeSH
OBJECTIVES: To investigate the associations between antibody responses to herpesviruses and the development of thalamic, total deep gray matter, cortical and central atrophy in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. METHODS: We analyzed volumetric brain outcomes in 193 CIS patients enrolled in a multi-center study of high-risk CIS. All patients had 2 or more MRI brain lesions and two or more oligoclonal bands in cerebrospinal fluid. Serum samples obtained at the screening visit prior to any treatment were analyzed for IgG antibodies against cytomegalovirus (anti-CMV) and Epstein-Barr virus (EBV) viral capsid antigen (VCA). All patients were treated with interferon-beta. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months. RESULTS: Anti-EBV VCA highest quartile status was associated with regional atrophy measures for percent decrease in thalamus. Anti-CMV positivity was associated with greater total deep gray matter atrophy and whole brain atrophy. Anti-EBV VCA highest quartile status was associated as trends with greater whole brain, gray matter atrophy and central atrophy. The associations of anti-EBV VCA antibodies with thalamic atrophy were mediated by its associations with T2 lesions whereas the associations of anti-CMV positivity with deep gray matter atrophy were relatively independent of T2 lesions. CONCLUSIONS: Antibody responses to EBV and CMV are associated with global and regional brain atrophy in CIS patients treated with interferon-beta.
Department of Neurology State University of New York Buffalo NY USA
Department of Pharmaceutical Sciences State University of New York Buffalo NY USA
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