Three months of regular aerobic exercise in patients with obesity improve systemic subclinical inflammation without major influence on blood pressure and endocrine production of subcutaneous fat
Language English Country Czech Republic Media print
Document type Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24908236
DOI
10.33549/physiolres.932792
PII: 932792
Knihovny.cz E-resources
- MeSH
- Adipokines blood genetics MeSH
- Arterial Pressure * MeSH
- Biomarkers blood MeSH
- Time Factors MeSH
- Cytokines blood genetics MeSH
- Hypertension diagnosis physiopathology MeSH
- Insulin Resistance MeSH
- Middle Aged MeSH
- Humans MeSH
- Inflammation Mediators blood MeSH
- RNA, Messenger blood MeSH
- Obesity blood diagnosis physiopathology therapy MeSH
- Subcutaneous Fat metabolism MeSH
- Exercise Therapy * MeSH
- Treatment Outcome MeSH
- Inflammation blood diagnosis genetics therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Controlled Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adipokines MeSH
- Biomarkers MeSH
- Cytokines MeSH
- Inflammation Mediators MeSH
- RNA, Messenger MeSH
The aim of our study was to explore the effects of regular aerobic exercise on anthropometric, biochemical and hormonal parameters and mRNA expression of selected factors involved in metabolic regulations in subcutaneous adipose tissue of patients with obesity. Fifteen obese women with arterial hypertension underwent a three-month exercise program consisting of 30 min of aerobic exercise 3 times a week. Fifteen healthy lean women with no intervention served as a control group. Obese group underwent anthropometric measurements, blood sampling, subcutaneous adipose tissue (SCAT) biopsy and 24-h blood pressure monitoring at baseline and after three months of exercise, while control group was examined only once. At baseline, obese group had increased SCAT expression of proinflammatory cytokines and adipokines relative to control group. Three months of regular exercise improved anthropometric parameters, decreased CRP, blood glucose and HOMA-IR, while having no significant effect on lipid profile and blood pressure. Gene expressions in SCAT were not affected by physical activity with the exception of increased aquaporin-3 mRNA expression. We conclude that three months of regular exercise decrease systemic subclinical inflammation with only minor influence on the blood pressure and the endocrine function of subcutaneous fat.
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