Decreased circulating visfatin is associated with improved disease activity in early rheumatoid arthritis: data from the PERAC cohort
Language English Country United States Media electronic-ecollection
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25068448
PubMed Central
PMC4113419
DOI
10.1371/journal.pone.0103495
PII: PONE-D-14-17392
Knihovny.cz E-resources
- MeSH
- Antirheumatic Agents therapeutic use MeSH
- C-Reactive Protein metabolism MeSH
- Time Factors MeSH
- Cholesterol blood MeSH
- Adult MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Linear Models MeSH
- Lipids blood MeSH
- Multivariate Analysis MeSH
- Nicotinamide Phosphoribosyltransferase blood MeSH
- Arthritis, Rheumatoid blood drug therapy pathology MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antirheumatic Agents MeSH
- C-Reactive Protein MeSH
- Cholesterol MeSH
- Lipids MeSH
- Nicotinamide Phosphoribosyltransferase MeSH
OBJECTIVE: To evaluate circulating visfatin and its relationship with disease activity and serum lipids in patients with early, treatment-naïve rheumatoid arthritis (RA). METHODS: Serum visfatin was measured in 40 patients with early RA before and after three months of treatment and in 30 age- and sex-matched healthy individuals. Disease activity was assessed using the Disease Activity Score for 28 joints (DAS28) at baseline and at three and 12 months. Multivariate linear regression analysis was performed to evaluate whether improved disease activity is related to serum visfatin or a change in visfatin level. RESULTS: Serum visfatin was significantly elevated in early RA patients compared to healthy controls (1.92±1.17 vs. 1.36±0.93 ng/ml; p = 0.034) and significantly decreased after three months of treatment (to 0.99±0.67 ng/ml; p<0.001). Circulating visfatin and a change in visfatin level correlated with disease activity and improved disease activity over time, respectively. A decrease in visfatin after three months predicted a DAS28 improvement after 12 months. In addition, decreased serum visfatin was not associated with an improved atherogenic index but was associated with an increase in total cholesterol level. CONCLUSION: A short-term decrease in circulating visfatin may represent an independent predictor of long-term disease activity improvement in patients with early RA.
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