Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25124059
DOI
10.1016/j.ijpharm.2014.08.014
PII: S0378-5173(14)00580-8
Knihovny.cz E-resources
- Keywords
- 2-hydroxypropanoic acid (PubChem CID:612), Chitosan, Chitosan (PubChem CID:71853), Doxorubicin, Doxorubicin (PubChem CID:31703), Drug delivery System, Nanoparticles, Polylactide, Temozolomide, Temozolomide (PubChem CID:5394),
- MeSH
- Chitosan administration & dosage chemistry MeSH
- Dacarbazine administration & dosage analogs & derivatives chemistry therapeutic use MeSH
- Doxorubicin administration & dosage chemistry therapeutic use MeSH
- Lactic Acid administration & dosage chemical synthesis chemistry MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Molecular Structure MeSH
- Nanoparticles administration & dosage chemistry MeSH
- Polyesters MeSH
- Polymers administration & dosage chemical synthesis chemistry MeSH
- Surface-Active Agents administration & dosage chemistry MeSH
- Surface Properties MeSH
- Temozolomide MeSH
- Temperature MeSH
- Particle Size MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chitosan MeSH
- Dacarbazine MeSH
- Doxorubicin MeSH
- Lactic Acid MeSH
- poly(lactide) MeSH Browser
- Polyesters MeSH
- Polymers MeSH
- Surface-Active Agents MeSH
- Temozolomide MeSH
The aim of this work was to investigate the potential of an amphiphilic system comprising chitosan-grafted polylactide and carboxyl-functionalized polylactide acid as a carrier for the controlled release and co-release of two DNA alkylating drugs: doxorubicin and temozolomide. Polylactide and carboxyl-functionalized polylactide acid were obtained through direct melt polycondensation reaction, using methanesulfonic acid as a non-toxic initiator, and subsequently these were grafted to the chitosan backbone through a coupling reaction, utilizing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a condensing agent. ATR-FTIR analysis and conductometric titration confirmed that a reaction between CS and PLA, PLACA2% and PLACA5% occurred. Chitosan-grafted-polylactide and polylactide-citric acid nanoparticles were prepared via the polyelectrolyte complex technique, applying dextran sulphate as a polyanion, and loaded with doxorubicin and temozolomide. The diameter of particles, ζ-potential and their relationship to temperature and pH were analysed in all formulations. Encapsulation, co-encapsulation efficiency and release studies were conducted in different physiological simulated environments and human serum. Results showed the continuous release of drugs without an initial burst in different physiological media.
References provided by Crossref.org
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