Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25124059
DOI
10.1016/j.ijpharm.2014.08.014
PII: S0378-5173(14)00580-8
Knihovny.cz E-zdroje
- Klíčová slova
- 2-hydroxypropanoic acid (PubChem CID:612), Chitosan, Chitosan (PubChem CID:71853), Doxorubicin, Doxorubicin (PubChem CID:31703), Drug delivery System, Nanoparticles, Polylactide, Temozolomide, Temozolomide (PubChem CID:5394),
- MeSH
- chitosan aplikace a dávkování chemie MeSH
- dakarbazin aplikace a dávkování analogy a deriváty chemie terapeutické užití MeSH
- doxorubicin aplikace a dávkování chemie terapeutické užití MeSH
- kyselina mléčná aplikace a dávkování chemická syntéza chemie MeSH
- lidé MeSH
- molekulární struktura MeSH
- nanočástice aplikace a dávkování chemie MeSH
- polyestery MeSH
- polymery aplikace a dávkování chemická syntéza chemie MeSH
- povrchově aktivní látky aplikace a dávkování chemie MeSH
- povrchové vlastnosti MeSH
- systémy cílené aplikace léků * MeSH
- temozolomid MeSH
- teplota MeSH
- velikost částic MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chitosan MeSH
- dakarbazin MeSH
- doxorubicin MeSH
- kyselina mléčná MeSH
- poly(lactide) MeSH Prohlížeč
- polyestery MeSH
- polymery MeSH
- povrchově aktivní látky MeSH
- temozolomid MeSH
The aim of this work was to investigate the potential of an amphiphilic system comprising chitosan-grafted polylactide and carboxyl-functionalized polylactide acid as a carrier for the controlled release and co-release of two DNA alkylating drugs: doxorubicin and temozolomide. Polylactide and carboxyl-functionalized polylactide acid were obtained through direct melt polycondensation reaction, using methanesulfonic acid as a non-toxic initiator, and subsequently these were grafted to the chitosan backbone through a coupling reaction, utilizing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a condensing agent. ATR-FTIR analysis and conductometric titration confirmed that a reaction between CS and PLA, PLACA2% and PLACA5% occurred. Chitosan-grafted-polylactide and polylactide-citric acid nanoparticles were prepared via the polyelectrolyte complex technique, applying dextran sulphate as a polyanion, and loaded with doxorubicin and temozolomide. The diameter of particles, ζ-potential and their relationship to temperature and pH were analysed in all formulations. Encapsulation, co-encapsulation efficiency and release studies were conducted in different physiological simulated environments and human serum. Results showed the continuous release of drugs without an initial burst in different physiological media.
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