Pilot study of sex differences in QTc intervals of heart transplant recipients
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
PG/12/77/29857
British Heart Foundation - United Kingdom
PG/13/54/30358
British Heart Foundation - United Kingdom
PubMed
25175174
DOI
10.1016/j.jelectrocard.2014.07.015
PII: S0022-0736(14)00289-1
Knihovny.cz E-zdroje
- Klíčová slova
- Cardiac repolarization, Heart transplantation, Sex differences,
- MeSH
- dárci tkání statistika a číselné údaje MeSH
- dospělí MeSH
- elektrokardiografie ambulantní statistika a číselné údaje MeSH
- lidé středního věku MeSH
- lidé MeSH
- pilotní projekty MeSH
- pohlavní dimorfismus MeSH
- příjemce transplantátu statistika a číselné údaje MeSH
- rozložení podle pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srdeční frekvence * MeSH
- srdeční selhání epidemiologie patofyziologie chirurgie MeSH
- transplantace srdce statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
BACKGROUND: Repolarization processes in female and male are different. This study provided pilot data on automatic measurements of QT intervals in heart transplant (HT) recipients stratified according to the sex of the recipient and the donor. METHODS AND RESULTS: The following groups were analyzed: Group A-20 males with male heart, group B-14 females with male heart, group C-13 females with female heart, group D-11 males with female heart, group E-20 healthy males, and group F-20 healthy females. Twelve-lead electrocardiograms were digitally captured during autonomic provocative test of five postural 8-minute stages-supine, unsupported sitting, supine, unsupported standing, and supine. Fridericia formula was used for heart rate correction together with a generic correction for QT/RR hysteresis. Neither female nor male HT recipients exhibit any differences in QTc interval duration related to the sex of the donor. There was, however, a trend towards longer QTc intervals in female HT recipients compared to male HT recipients irrespective of the sex of the donor. The QTc differences between healthy control females and males were highly statistically significant proving the assay sensitivity of the study. CONCLUSION: The available pilot data suggest that in HT patients, the sex of the donor has little influence on the QTc interval of the transplanted heart.
International Clinical Research Center St Anne´s University Hospital Brno Czech Republic
St Paul's Cardiac Electrophysiology and Imperial College London United Kingdom
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