Pilot study of sex differences in QTc intervals of heart transplant recipients
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
PG/12/77/29857
British Heart Foundation - United Kingdom
PG/13/54/30358
British Heart Foundation - United Kingdom
PubMed
25175174
DOI
10.1016/j.jelectrocard.2014.07.015
PII: S0022-0736(14)00289-1
Knihovny.cz E-resources
- Keywords
- Cardiac repolarization, Heart transplantation, Sex differences,
- MeSH
- Tissue Donors statistics & numerical data MeSH
- Adult MeSH
- Electrocardiography, Ambulatory statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Pilot Projects MeSH
- Sex Characteristics MeSH
- Transplant Recipients statistics & numerical data MeSH
- Sex Distribution MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Heart Rate * MeSH
- Heart Failure epidemiology physiopathology surgery MeSH
- Heart Transplantation statistics & numerical data MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
BACKGROUND: Repolarization processes in female and male are different. This study provided pilot data on automatic measurements of QT intervals in heart transplant (HT) recipients stratified according to the sex of the recipient and the donor. METHODS AND RESULTS: The following groups were analyzed: Group A-20 males with male heart, group B-14 females with male heart, group C-13 females with female heart, group D-11 males with female heart, group E-20 healthy males, and group F-20 healthy females. Twelve-lead electrocardiograms were digitally captured during autonomic provocative test of five postural 8-minute stages-supine, unsupported sitting, supine, unsupported standing, and supine. Fridericia formula was used for heart rate correction together with a generic correction for QT/RR hysteresis. Neither female nor male HT recipients exhibit any differences in QTc interval duration related to the sex of the donor. There was, however, a trend towards longer QTc intervals in female HT recipients compared to male HT recipients irrespective of the sex of the donor. The QTc differences between healthy control females and males were highly statistically significant proving the assay sensitivity of the study. CONCLUSION: The available pilot data suggest that in HT patients, the sex of the donor has little influence on the QTc interval of the transplanted heart.
International Clinical Research Center St Anne´s University Hospital Brno Czech Republic
St Paul's Cardiac Electrophysiology and Imperial College London United Kingdom
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