Cancer-associated fibroblasts are not formed from cancer cells by epithelial-to-mesenchymal transition in nu/nu mice
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adenocarcinoma metabolism pathology MeSH
- Cell Lineage * MeSH
- HT29 Cells MeSH
- Stromal Cells metabolism pathology MeSH
- Time Factors MeSH
- Squamous Cell Carcinoma of Head and Neck MeSH
- Epithelial-Mesenchymal Transition * MeSH
- Fibroblasts metabolism pathology MeSH
- Heterografts MeSH
- Colorectal Neoplasms metabolism pathology MeSH
- Humans MeSH
- Mice, Nude MeSH
- Biomarkers, Tumor metabolism MeSH
- Head and Neck Neoplasms metabolism pathology MeSH
- Pharyngeal Neoplasms metabolism pathology MeSH
- Carcinoma, Squamous Cell metabolism pathology MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
Cancer-associated fibroblasts are bioactive elements influencing the biological properties of malignant tumors. Their origin from different cell types has been established, and the possibility of their formation by epithelial-to-mesenchymal transition from cancer cells is under debate. This study shows that human cancer cells grafted to nu/nu mice induced formation of tumor stroma with the presence of typical smooth muscle actin-containing cancer-associated fibroblasts. These cells seem to be of the host origin because they are not recognized by an antibody specific for human vimentin, as was also verified in vitro. These results suggest that cancer-associated stromal fibroblasts are not formed by epithelial-to-mesenchymal transition from cancer cells.
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