Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25559385
DOI
10.1016/j.virol.2014.12.011
PII: S0042-6822(14)00548-0
Knihovny.cz E-zdroje
- Klíčová slova
- Arenavirus, Ecology, Hemorrhagic fevers, Mastomys natalensis, Phylogeny, Tanzania, Virology, Zoonotic infections,
- MeSH
- Arenavirus klasifikace genetika izolace a purifikace MeSH
- fylogeneze MeSH
- genetická variace * MeSH
- infekce viry z čeledi Arenaviridae imunologie veterinární virologie MeSH
- molekulární sekvence - údaje MeSH
- Murinae imunologie virologie MeSH
- nemoci hlodavců imunologie virologie MeSH
- protilátky virové imunologie MeSH
- virus Lassa klasifikace genetika izolace a purifikace MeSH
- zdroje nemoci virologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Tanzanie MeSH
- Názvy látek
- protilátky virové MeSH
Despite its near pan-African range, the Natal multimammate mouse, Mastomys natalensis, carries the human pathogen Lassa virus only in West Africa, while the seemingly non-pathogenic arenaviruses Mopeia, Morogoro, and Luna have been detected in this semi-commensal rodent in Mozambique/Zimbabwe, Tanzania and Zambia, respectively. Here, we describe a novel arenavirus in M. natalensis from Gairo district of central Tanzania, for which we propose the name "Gairo virus". Surprisingly, the virus is not closely related with Morogoro virus that infects M. natalensis only 90km south of Gairo, but clusters phylogenetically with Mobala-like viruses that infect non-M. natalensis host species in Central African Republic and Ethiopia. Despite the evolutionary distance, Gairo virus shares basic ecological features with the other M. natalensis-borne viruses Lassa and Morogoro. Our data show that M. natalensis, carrying distantly related viruses even in the same geographical area, is a potent reservoir host for a variety of arenaviruses.
Department of Virology Bernard Nocht Institute for Tropical Medicine Hamburg Germany
Evolutionary Ecology Group Department of Biology University of Antwerp Antwerp Belgium
Pest Management Centre Sokoine University of Agriculture Morogoro Tanzania
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