Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25559385
DOI
10.1016/j.virol.2014.12.011
PII: S0042-6822(14)00548-0
Knihovny.cz E-resources
- Keywords
- Arenavirus, Ecology, Hemorrhagic fevers, Mastomys natalensis, Phylogeny, Tanzania, Virology, Zoonotic infections,
- MeSH
- Arenavirus classification genetics isolation & purification MeSH
- Phylogeny MeSH
- Genetic Variation * MeSH
- Arenaviridae Infections immunology veterinary virology MeSH
- Molecular Sequence Data MeSH
- Murinae immunology virology MeSH
- Rodent Diseases immunology virology MeSH
- Antibodies, Viral immunology MeSH
- Lassa virus classification genetics isolation & purification MeSH
- Disease Reservoirs virology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Tanzania MeSH
- Names of Substances
- Antibodies, Viral MeSH
Despite its near pan-African range, the Natal multimammate mouse, Mastomys natalensis, carries the human pathogen Lassa virus only in West Africa, while the seemingly non-pathogenic arenaviruses Mopeia, Morogoro, and Luna have been detected in this semi-commensal rodent in Mozambique/Zimbabwe, Tanzania and Zambia, respectively. Here, we describe a novel arenavirus in M. natalensis from Gairo district of central Tanzania, for which we propose the name "Gairo virus". Surprisingly, the virus is not closely related with Morogoro virus that infects M. natalensis only 90km south of Gairo, but clusters phylogenetically with Mobala-like viruses that infect non-M. natalensis host species in Central African Republic and Ethiopia. Despite the evolutionary distance, Gairo virus shares basic ecological features with the other M. natalensis-borne viruses Lassa and Morogoro. Our data show that M. natalensis, carrying distantly related viruses even in the same geographical area, is a potent reservoir host for a variety of arenaviruses.
Department of Virology Bernard Nocht Institute for Tropical Medicine Hamburg Germany
Evolutionary Ecology Group Department of Biology University of Antwerp Antwerp Belgium
Pest Management Centre Sokoine University of Agriculture Morogoro Tanzania
References provided by Crossref.org
Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses
Multiple Mammarenaviruses Circulating in Angolan Rodents
Molecular detection and genomic characterization of diverse hepaciviruses in African rodents
