Hormonal enhancement of insecticide efficacy in Tribolium castaneum: oxidative stress and metabolic aspects
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25661030
DOI
10.1016/j.cbpc.2015.01.005
PII: S1532-0456(15)00006-X
Knihovny.cz E-zdroje
- Klíčová slova
- Adipokinetic hormone, Insecticide, Metabolism, Mortality, Oxidative stress, RNA interference,
- MeSH
- energetický metabolismus účinky léků fyziologie MeSH
- hmyzí hormony aplikace a dávkování toxicita MeSH
- insekticidy aplikace a dávkování toxicita MeSH
- kyselina pyrrolidonkarboxylová aplikace a dávkování analogy a deriváty toxicita MeSH
- neuropeptidy aplikace a dávkování toxicita MeSH
- oxidační stres účinky léků fyziologie MeSH
- Tribolium účinky léků metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adipokinetic hormone, beetle MeSH Prohlížeč
- hmyzí hormony MeSH
- insekticidy MeSH
- kyselina pyrrolidonkarboxylová MeSH
- neuropeptidy MeSH
Insect anti-stress responses, including those induced by insecticides, are controlled by adipokinetic hormones (AKHs). We examined the physiological consequences of Pyrap-AKH application on Tribolium castaneum adults (AKH-normal and AKH-deficient prepared by the RNAi technique) treated by two insecticides, pirimiphos-methyl and deltamethrin. Co-application of pirimiphos-methyl and/or deltamethrin with AKH significantly increased beetle mortality compared with application of the insecticides alone. This co-treatment was accompanied by substantial stimulation of general metabolism, as monitored by carbon dioxide production. Further, the insecticide treatment alone affected some basic markers of oxidative stress: it lowered total antioxidative capacity as well as the activity of superoxide dismutase in the beetle body; in addition, it enhanced the activity of catalase and glutathione-S-transferase. However, these discrepancies in oxidative stress markers were eliminated/reduced by co-application with Pyrap-AKH. We suggest that the elevation of metabolism, which is probably accompanied with faster turnover of toxins, might be responsible for the higher mortality that results after AKH and insecticide co-application. Changes in oxidative stress markers are probably not included in the mechanisms responsible for increased mortality.
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