Hormonal enhancement of insecticide efficacy in Tribolium castaneum: oxidative stress and metabolic aspects
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25661030
DOI
10.1016/j.cbpc.2015.01.005
PII: S1532-0456(15)00006-X
Knihovny.cz E-resources
- Keywords
- Adipokinetic hormone, Insecticide, Metabolism, Mortality, Oxidative stress, RNA interference,
- MeSH
- Energy Metabolism drug effects physiology MeSH
- Insect Hormones administration & dosage toxicity MeSH
- Insecticides administration & dosage toxicity MeSH
- Pyrrolidonecarboxylic Acid administration & dosage analogs & derivatives toxicity MeSH
- Neuropeptides administration & dosage toxicity MeSH
- Oxidative Stress drug effects physiology MeSH
- Tribolium drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- adipokinetic hormone, beetle MeSH Browser
- Insect Hormones MeSH
- Insecticides MeSH
- Pyrrolidonecarboxylic Acid MeSH
- Neuropeptides MeSH
Insect anti-stress responses, including those induced by insecticides, are controlled by adipokinetic hormones (AKHs). We examined the physiological consequences of Pyrap-AKH application on Tribolium castaneum adults (AKH-normal and AKH-deficient prepared by the RNAi technique) treated by two insecticides, pirimiphos-methyl and deltamethrin. Co-application of pirimiphos-methyl and/or deltamethrin with AKH significantly increased beetle mortality compared with application of the insecticides alone. This co-treatment was accompanied by substantial stimulation of general metabolism, as monitored by carbon dioxide production. Further, the insecticide treatment alone affected some basic markers of oxidative stress: it lowered total antioxidative capacity as well as the activity of superoxide dismutase in the beetle body; in addition, it enhanced the activity of catalase and glutathione-S-transferase. However, these discrepancies in oxidative stress markers were eliminated/reduced by co-application with Pyrap-AKH. We suggest that the elevation of metabolism, which is probably accompanied with faster turnover of toxins, might be responsible for the higher mortality that results after AKH and insecticide co-application. Changes in oxidative stress markers are probably not included in the mechanisms responsible for increased mortality.
References provided by Crossref.org
Elimination of certain honeybee venom activities by adipokinetic hormone
Hormonal Regulation of Response to Oxidative Stress in Insects-An Update
