Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- HPMA copolymers, drug delivery systems, pH-controlled release, reversible addition fragmentation chain transfer (RAFT), star copolymers,
- MeSH
- Dendrimers * chemical synthesis chemistry pharmacokinetics pharmacology MeSH
- Doxorubicin * chemistry pharmacokinetics pharmacology MeSH
- Delayed-Action Preparations chemical synthesis chemistry pharmacokinetics pharmacology MeSH
- Humans MeSH
- Methacrylates * chemistry pharmacokinetics pharmacology MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Neoplasms * drug therapy metabolism pathology MeSH
- Nanoparticles chemistry ultrastructure MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dendrimers * MeSH
- Doxorubicin * MeSH
- hydroxypropyl methacrylate MeSH Browser
- Delayed-Action Preparations MeSH
- Methacrylates * MeSH
- PAMAM Starburst MeSH Browser
High-molecular-weight star polymer drug nanocarriers intended for the treatment and/or visualisation of solid tumours were synthesised, and their physico-chemical and preliminary in vitro biological properties were determined. The water-soluble star polymer carriers were prepared by the grafting of poly(amido amine) (PAMAM) dendrimers by hetero-telechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, synthesised by the controlled radical Reversible Addition Fragmentation chain Transfer (RAFT) polymerisation. The well-defined star copolymers with Mw values ranging from 2 · 10(5) to 6 · 10(5) showing a low dispersity (approximately 1.2) were prepared in a high yield. A model anticancer drug, doxorubicin, was bound to the star polymer through a hydrazone bond, enabling the pH-controlled drug release in the target tumour tissue. The activated polymer arm ends of the star copolymer carrier enable a one-point attachment for the targeting ligands and/or a labelling moiety. In this study, the model TAMRA fluorescent dye was used to prove the feasibility of the polymer carrier visualisation by optical imaging in vitro. The tailor-made structure of the star polymer carriers should facilitate the synthesis of targeted polymer-drug conjugates, even polymer theranostics, for simultaneous tumour drug delivery and imaging.
References provided by Crossref.org
HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
