Macrophage subsets in the adipose tissue could be modified by sex and the reproductive age of women
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
25795161
DOI
10.1016/j.atherosclerosis.2015.03.018
PII: S0021-9150(15)00178-1
Knihovny.cz E-zdroje
- Klíčová slova
- Adipose tissue, Monocytes/macrophages, Reproductive status, Sex,
- MeSH
- biologické markery analýza MeSH
- disparity zdravotního stavu * MeSH
- dospělí MeSH
- GPI-vázané proteiny analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipopolysacharidové receptory analýza MeSH
- makrofágy imunologie MeSH
- postmenopauza MeSH
- premenopauza MeSH
- receptory IgG analýza MeSH
- rizikové faktory MeSH
- rozmnožování * MeSH
- senioři MeSH
- sexuální faktory MeSH
- stárnutí imunologie MeSH
- tuková tkáň imunologie MeSH
- věkové faktory MeSH
- zánět imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- biologické markery MeSH
- FCGR3B protein, human MeSH Prohlížeč
- GPI-vázané proteiny MeSH
- lipopolysacharidové receptory MeSH
- receptory IgG MeSH
The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented in conditions of inflammation, such as atherosclerosis. We analysed the proportion of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy living kidney donors with regard to sex and age reflecting reproductive status in women; therefore, women were further divided to younger and older group (younger and older than 51 years) reflecting potential age of menopause. Monocyte/macrophages were identified as CD14+ mononuclear cells and divided into subpopulations based on the co-expression of CD16. We found no differences in the monocyte/macrophage content between men (n = 15) and women (n = 28). Conversely, we observed a higher proportion of double positive CD14+CD16+ monocytes/macrophages in older women (n = 14) compared to younger women (n = 14). In addition, a strong correlation was found between the monocyte/macrophage content in fat and age only in older women. Therefore, proinflammatory monocytes/macrophages (CD14+CD16+) should be evaluated according to the sex and age.
Transplant Surgery Department Institute for Clinical and Experimental Medicine Prague Czech Republic
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