Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25863351
DOI
10.1016/j.fitote.2015.04.004
PII: S0367-326X(15)00094-5
Knihovny.cz E-resources
- Keywords
- Argemonine (CID: 442168), Berberine (PubChem CID: 2353), Californidine, Californidine (PubChem CID: 45266443), Canadine (PubChem CID: 443422), Corynoline (PubChem CID: 177014), Corypalmine (PubChem CID: 185605), Dihydrosanquinarine, Dihydrosanquinarine (PubChem CID: 124069), Isoquinoline alkaloids, N-Methyllaurotetanine (PubChem CID: 16573), Prolyl oligopeptidase,
- MeSH
- Alkaloids chemistry MeSH
- Aporphines chemistry MeSH
- Dioxoles chemistry MeSH
- Heterocyclic Compounds, 4 or More Rings chemistry MeSH
- Serine Proteinase Inhibitors chemistry MeSH
- Isoquinolines chemistry MeSH
- Molecular Structure MeSH
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkaloids MeSH
- Aporphines MeSH
- californidine MeSH Browser
- corypalmine MeSH Browser
- Dioxoles MeSH
- Heterocyclic Compounds, 4 or More Rings MeSH
- Serine Proteinase Inhibitors MeSH
- Isoquinolines MeSH
- N-methyllaurotetanine MeSH Browser
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases MeSH
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50=55.6±3.5 μM), dihydrosanquinarine (IC50=99.1±7.6 μM), corypalmine (IC50=128.0±10.5 μM) and N-methyllaurotetanine (IC50=135.0±11.7 μM).
References provided by Crossref.org
Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors
