Delayed Effect of the Light Pulse on Phosphorylated ERK1/2 and GSK3β Kinases in the Ventrolateral Suprachiasmatic Nucleus of Rat
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- cirkadiánní hodiny * MeSH
- kinasa 3 glykogensynthasy metabolismus MeSH
- kinasa glykogensynthasy 3beta MeSH
- krysa rodu Rattus MeSH
- MAP kinasový signální systém MeSH
- mitogenem aktivovaná proteinkinasa 1 metabolismus MeSH
- mitogenem aktivovaná proteinkinasa 3 metabolismus MeSH
- nucleus suprachiasmaticus metabolismus fyziologie MeSH
- potkani Wistar MeSH
- reakční čas * MeSH
- světelná stimulace MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- Gsk3b protein, rat MeSH Prohlížeč
- kinasa 3 glykogensynthasy MeSH
- kinasa glykogensynthasy 3beta MeSH
- mitogenem aktivovaná proteinkinasa 1 MeSH
- mitogenem aktivovaná proteinkinasa 3 MeSH
The intrinsic period of circadian clock in the suprachiasmatic nucleus is entrained to a 24-h cycle by external cues, mainly light. Previous studies have shown that light applied at night induces robust phosphorylation of extracellular-signal-regulated kinase that is necessary to process the light pulse into the phase shift of the clock phase. In this study, we show the persistent downregulation of phosphorylated extracellular-signal-regulated kinase and transient downregulation of phosphorylated glycogen synthase kinase-3beta in the ventrolateral part of the suprachiasmatic nucleus to photic stimuli starting at 2 h after the beginning of the light pulse. As both kinases are involved in regulation of circadian clockwork, we hypothesize that these changes may contribute to the phase-shifting effect of light at night.
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