Neointimal coverage and late apposition of everolimus-eluting bioresorbable scaffolds implanted in the acute phase of myocardial infarction: OCT data from the PRAGUE-19 study
Jazyk angličtina Země Japonsko Médium print-electronic
Typ dokumentu klinická studie, časopisecké články
PubMed
25896128
DOI
10.1007/s00380-015-0679-8
PII: 10.1007/s00380-015-0679-8
Knihovny.cz E-zdroje
- Klíčová slova
- Acute myocardial infarction, Biodegradable vascular scaffold, Late apposition, Neointimal coverage,
- MeSH
- biokompatibilní potahované materiály * MeSH
- časové faktory MeSH
- everolimus aplikace a dávkování škodlivé účinky MeSH
- infarkt myokardu s elevacemi ST úseků diagnostické zobrazování terapie MeSH
- kardiovaskulární látky aplikace a dávkování škodlivé účinky MeSH
- koronární angiografie MeSH
- koronární angioplastika škodlivé účinky přístrojové vybavení MeSH
- koronární cévy diagnostické zobrazování účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- neointima * MeSH
- optická koherentní tomografie MeSH
- prospektivní studie MeSH
- protézy - design MeSH
- senioři MeSH
- vstřebatelné implantáty * MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinická studie MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- biokompatibilní potahované materiály * MeSH
- everolimus MeSH
- kardiovaskulární látky MeSH
Incomplete stent apposition and uncovered struts are associated with a higher risk of stent thrombosis. No data exist on the process of neointimal coverage and late apposition status of the bioresorbable vascular scaffold (BVS) when implanted in the highly thrombogenic setting of ST-segment elevation acute myocardial infarction (STEMI). The aim of this study was to assess the serial changes in strut apposition and early neointimal coverage of the BVS using optical coherence tomography (OCT) in selected patients enrolled in the PRAGUE-19 study. Intracoronary OCT was performed in 50 patients at the end of primary percutaneous coronary intervention for acute STEMI. Repeated OCT of the implanted BVS was performed in 10 patients. Scaffold area, scaffold mean diameter and incomplete strut apposition (ISA) were compared between baseline and control OCT. Furthermore, strut neointimal coverage was assessed during the control OCT. Mean scaffold area and diameter did not change between the baseline and control OCT (8.59 vs. 9.06 mm(2); p = 0.129 and 3.31 vs. 3.37 mm; p = 0.202, respectively). Differences were observed in ISA between the baseline and control OCT (0.63 vs. 1.47 %; p < 0.05). We observed 83.1 % covered struts in eight patients in whom the control OCT was performed 4-6 weeks after BVS implantation, and 100 % covered struts in two patients 6 months after BVS implantation. Persistent strut apposition and early neointimal coverage were observed after biodegradable vascular scaffold implantation in patients with acute ST-segment elevation myocardial infarction.
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