Blood coagulation and platelet adhesion on polyaniline films
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26119372
DOI
10.1016/j.colsurfb.2015.06.008
PII: S0927-7765(15)00380-X
Knihovny.cz E-zdroje
- Klíčová slova
- Blood coagulation, Hemocompatibility, Platelet adhesion, Poly(2-acrylamido-2-methyl-1-propanesulfonic acid), Polyaniline,
- MeSH
- aniliny * MeSH
- buněčná adheze * MeSH
- hemokoagulace * MeSH
- lidé MeSH
- spektrofotometrie ultrafialová MeSH
- trombocyty cytologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aniliny * MeSH
- polyaniline MeSH Prohlížeč
Polyaniline is a promising conducting polymer with still increasing application potential in biomedicine. Its surface modification can be an efficient way how to introduce desired functional groups and to control its properties while keeping the bulk characteristics of the material unchanged. The purpose of the study was to synthetize thin films of pristine conducting polyaniline hydrochloride, non-conducting polyaniline base and polyaniline modified with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPSA) and investigate chosen parameters of their hemocompatibility. The modification was performed either by introduction of PAMPSA during the synthesis or by reprotonation of polyaniline base. The polyaniline hydrochloride and polyaniline base had no impact on blood coagulation and platelet adhesion. By contrast, the polyaniline reprotonated with PAMPSA completely hindered coagulation thanks to its interaction with coagulation factors Xa, Va and IIa. The significantly lower platelets adhesion was also found on this surface. Moreover, this film maintains its conductivity at pH of 6, which is an improvement in comparison with standard polyaniline hydrochloride losing most of its conductivity at pH of 4. Polyaniline film with PAMPSA introduced during synthesis had an impact on platelet adhesion but not on coagulation. The combined conductivity, anticoagulation activity, low platelet adhesion and improved conductivity at pH closer to physiological, open up new possibilities for application of polyaniline reprotonated by PAMPSA in blood-contacting devices, such as catheters or blood vessel grafts.
Centre of Polymer Systems Tomas Bata University in Zlin 760 01 Zlin Czech Republic
Department of Surface Engineering Plasma Laboratory Josef Stefan Institute 1000 Ljubljana Slovenia
Citace poskytuje Crossref.org
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