The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26229021
DOI
10.1007/s00428-015-1812-x
PII: 10.1007/s00428-015-1812-x
Knihovny.cz E-resources
- Keywords
- Human papillomavirus (HPV), Nonkeratinizing, RNA, Sinonasal carcinoma, Squamous cell carcinoma, p16 protein,
- MeSH
- Squamous Cell Carcinoma of Head and Neck MeSH
- DNA, Viral analysis MeSH
- Adult MeSH
- Transcription, Genetic MeSH
- Immunohistochemistry MeSH
- Cyclin-Dependent Kinase Inhibitor p16 MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger analysis MeSH
- Neoplasm Proteins analysis MeSH
- Head and Neck Neoplasms mortality pathology virology MeSH
- Paranasal Sinus Neoplasms mortality pathology virology MeSH
- Oncogene Proteins, Viral genetics MeSH
- Papillomaviridae isolation & purification MeSH
- Papillomavirus E7 Proteins genetics MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Repressor Proteins genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Carcinoma, Squamous Cell mortality pathology virology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- CDKN2A protein, human MeSH Browser
- DNA, Viral MeSH
- E6 protein, Human papillomavirus type 16 MeSH Browser
- Cyclin-Dependent Kinase Inhibitor p16 MeSH
- RNA, Messenger MeSH
- Neoplasm Proteins MeSH
- oncogene protein E7, Human papillomavirus type 16 MeSH Browser
- Oncogene Proteins, Viral MeSH
- Papillomavirus E7 Proteins MeSH
- Repressor Proteins MeSH
The aim of the study was to investigate prevalence of high-risk human papillomavirus (HR-HPV) infection in sinonasal carcinomas by immunohistochemistry, in situ hybridization, and polymerase chain reaction, detecting p16(INK4a) protein (p16) expression and presence of both HPV DNA and HPV E6/E7 messenger RNA (mRNA). The study comprised 47 males and 26 females, aged 23-83 years (median 62 years), mostly (67 %) with a squamous cell carcinoma (SCC). Of the tumors, 53 % arose in the nasal cavity, 42 % in the maxillary sinus, and 5 % in the ethmoid complex. The follow-up period ranged 1-241 months (median 19 months). HPV16, HPV18, or HPV35 were detected in 18/73 (25 %) tumors, 17 SCCs, and 1 small cell neuroendocrine carcinoma. There was a strong correlation between results of HPV detection methods and p16 expression (p < 0.005). HPV-positive SCCs occurred more frequently in smokers (p = 0.04) and were more frequently p16-positive (p < 0.0001) and nonkeratinizing (p = 0.02), the latter occurring more commonly in nasal cavity (p = 0.025). Median survival for HPV-positive SCC patients was 30 months, while for HPV-negative SCC patients was 14 months (p = 0.23). In summary, we confirm that HR-HPV is actively involved in the etiopathogenesis of a significant subset of sinonasal SCCs. p16 may be used as a reliable surrogate marker for determination of HPV status also in sinonasal SCCs. Although we observed a trend toward better overall survival in HPV-positive SCCs, the prognostic impact of HPV status in sinonasal carcinomas needs to be elucidated by further studies.
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