Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26255233
DOI
10.1016/j.jinorgbio.2015.07.014
PII: S0162-0134(15)30043-X
Knihovny.cz E-resources
- Keywords
- Antitumor, Bacterial cells, Bacterial filamentation, Cellular target, DNA, Prophage induction, Transplatinum,
- MeSH
- Cisplatin chemistry pharmacology MeSH
- DNA, Bacterial chemistry MeSH
- Escherichia coli drug effects MeSH
- Organoplatinum Compounds chemistry pharmacology MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cisplatin MeSH
- DNA, Bacterial MeSH
- Organoplatinum Compounds MeSH
- Antineoplastic Agents MeSH
- transplatin MeSH Browser
The effects of the two representatives of the antitumor transplatinum agents, trans-[PtCl2(methylamine)2] and trans-[PtCl2(NH3)(1-methyl-7-azaindole)] on bacterial growth were examined. The results show that these antitumor transplatinum agents can be grouped with the coordination Pt(II) compounds exhibiting antitumor activity and capable of inducing bacterial filamentation and initiate lysis in lysogenic bacteria. The results corroborate the thesis that DNA is the potential cellular target also for a class of antitumor derivatives of transplatin.
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