Translation in the mammalian oocyte in space and time
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26340983
DOI
10.1007/s00441-015-2269-6
PII: 10.1007/s00441-015-2269-6
Knihovny.cz E-resources
- Keywords
- Meiosis, Oocyte, RNA, RNP, Translation,
- MeSH
- Humans MeSH
- Meiosis MeSH
- Oocytes cytology metabolism MeSH
- Oogenesis MeSH
- Protein Biosynthesis * MeSH
- RNA analysis genetics MeSH
- Transcriptome MeSH
- Gene Expression Regulation, Developmental MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RNA MeSH
A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Post-transcriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
CEITEC Veterinary Research Institute Hudcova 296 70 621 00 Brno Czech Republic
Institute of Animal Physiology and Genetics ASCR Rumburska 89 277 21 Libechov Czech Republic
References provided by Crossref.org
CPEB3 Maintains Developmental Competence of the Oocyte
The translational oscillation in oocyte and early embryo development
Regulation of 4E-BP1 activity in the mammalian oocyte
