Structural Magnetic Resonance Imaging Markers of Alzheimer's Disease and Its Retranslation to Rodent Models
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26401552
DOI
10.3233/jad-143195
PII: JAD143195
Knihovny.cz E-resources
- Keywords
- Alzheimer’s disease, diffusion tensor imaging, magnetic resonance imaging, rodent model,
- MeSH
- Alzheimer Disease diagnostic imaging metabolism pathology MeSH
- Biomarkers metabolism MeSH
- Humans MeSH
- Magnetic Resonance Imaging * methods MeSH
- Disease Models, Animal MeSH
- Brain diagnostic imaging metabolism pathology MeSH
- Radionuclide Imaging MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
The importance of imaging biomarkers has been acknowledged in the diagnosis and in the follow-up of Alzheimer's disease (AD), one of the major causes of dementia. Next to the molecular biomarkers and PET imaging investigations, structural MRI approaches provide important information about the disease progression and about the pathomechanism. Furthermore,a growing body of literature retranslates these imaging biomarkers to various rodent models of the disease. The goal of this review is to provide an overview of the macro- and microstructural imaging biomarkers of AD, concentrating on atrophy measures and diffusion MRI alterations. A survey is also given of the imaging approaches used in rodent models of dementias that can promote drug development.
Department of Neurology University of Szeged Szeged Hungary
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
References provided by Crossref.org
