Regulation of the Immune Response to α-Gal and Vector-borne Diseases
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26433250
DOI
10.1016/j.pt.2015.06.016
PII: S1471-4922(15)00153-1
Knihovny.cz E-resources
- Keywords
- alpha-gal, malaria, tick, vaccine, vector-borne diseases,
- MeSH
- Hypersensitivity immunology MeSH
- Arthropod Vectors immunology MeSH
- Immunoglobulin E immunology MeSH
- Disease Vectors * MeSH
- Host-Parasite Interactions immunology MeSH
- Humans MeSH
- Arthropod Proteins immunology MeSH
- Th2 Cells immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Immunoglobulin E MeSH
- Arthropod Proteins MeSH
Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-α-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of α-gal. Establishing the source of α-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.
SaBio Instituto de Investigación de Recursos Cinegéticos IREC CSIC UCLM JCCM 13005 Ciudad Real Spain
References provided by Crossref.org
Tick Bites Induce Anti-α-Gal Antibodies in Dogs
Environmental and Molecular Drivers of the α-Gal Syndrome
